Concepedia

Regio‐ and Enantioselective Allylic Amination of Aliphatic MBH Adducts with N‐Heteroaromatics

Haixia Wang, Lulu Yu, Ming‐Sheng Xie, Jiang Wu, Gui‐Rong Qu, Kuiling Ding, Hai‐Ming Guo

Chemistry - A European Journal · 2017 · 46 citations · 51 references

DOI

Concepts

Abstract

Palladium-catalyzed regio- and enantioselective allylic amination of aliphatic Morita-Baylis-Hillman (MBH) adducts with N-heteroaromatic nucleophiles (e.g., benzimidazole, 4,5-diphenylimidazole, benzotriazole, and purines) was achieved by using a spiroketal-based diphosphine (SKP) ligand, and afforded a range of chiral, branched N-allyl products with high selectivity.

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