Concepedia

A novel <i>PITX2</i> mutation in non‐syndromic orodental anomalies

Narin Intarak, Thanakorn Theerapanon, Chupong Ittiwut, Kanya Suphapeetiporn, Thantrira Porntaveetus, Vorasuk Shotelersuk

Oral Diseases · 2017 · 25 citations · 28 references

DOI

Abstract

This study for the first time demonstrates that the PITX2 mutation could lead to non-syndromic orodental anomalies in humans. We propose that the specific location in the C-terminal domain of PITX2 is exclusively necessary for tooth development.

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