<i>let-7</i> miRNA controls CED-7 homotypic adhesion and EFF-1–mediated axonal self-fusion to restore touch sensation following injury

Abstract

Significance In many organisms axonal fragments can rejoin by self-fusion after neuronal injury. It is hypothesized that cell fusion would be an efficient way to repair functional loss after injury. In this study, we tested this hypothesis using the Caenorhabditis elegans sensory neurons that are responsible for gentle touch sensation. We found that fusion between the proximal and distal fragments of an injured posterior touch neuron (the posterior lateral microtubule) promotes functional recovery in an age-dependent manner. We also discovered that let-7 miRNA inhibits functional restoration via EFF-1–mediated axonal self-fusion by reducing ced-7 expression. Our work established that the axon fusion process has functional significance in the maintenance of neuronal integrity throughout the life span of an organism.