Proceedings of the National Academy of Sciences · 2017 · 70 citations · 39 references
Life SciencesNeurobiologyNeuroscienceCellular NeuroscienceNeuroplasticitySynaptic PlasticityIon Channel RegulationNeural ExcitabilitySpike-timing-dependent PlasticityStructural Synaptic PlasticitySynaptic TransmissionAxon ExcitabilityAxon Initial Segment DynamicsExcitability RegulationExcitatory Pyramidal NeuronsNeuronal Circuit PlasticityNeuronal Excitability DisruptionNeuronal Excitability HomeostasisSynaptic Excitability
Significance The axon initial segment (AIS), the region where neurons generate spikes, was recently shown to be a highly dynamic structure, exhibiting plasticity over wide timescales. Here we triggered a unique form of AIS plasticity in hippocampal pyramidal neurons by selectively targeting the AIS M-type K + channels. We uncovered the mechanisms whereby sustained cholinergic activation or direct M-channel block rapidly trigger a unique form of AIS plasticity. Minutes to hours of sustained M-current depression resulted in a compensatory reduction in intrinsic excitability associated with distal shift of the axonal spike trigger zone and distal relocation of both Na + and M-channels. These fast homeostatic changes, necessary to stabilize network excitability, were dependent on the crucial AIS protein, protein kinase CK2.
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Distinct contributions of Nav1.6 and Nav1.2 in action potential initiation and backpropagation
Wenqin Hu, Cuiping Tian, Tun Li et al. · Nature Neuroscience · 2009 · 732 citations