Optimizing fresh specimen staining for rapid identification of tumor biomarkers during surgery

Abstract

DDSI provides a robust, molecularly specific imaging methodology for identifying tumor tissue over benign mammary adipose tissue. Using a dual probe imaging strategy, nonspecific accumulation of targeted probe was corrected for and tumor vs. normal tissue diagnostic potential was improved, circumventing difficulties with <i>ex vivo</i> tissue specimen staining and allowing for rapid clinical translation of this promising technology for tumor margin detection during BCS procedures.