Feasibility study on the use of gold nanoparticles in fractionated kilovoltage X-ray treatment of melanoma

Abstract

In addition to the benefit of AuNP treatment to the control of melanoma in single high-dose treatment, further therapeutic gain is expected through fractionated X-ray treatment that involves daily exposure. The AuNP-treated melanoma cells of an increased portion in the radiosensitive G₂/M phase following a fractionated dose delivery would respond to the next treatment with an enhanced chance of clonogenic death.