Synthesis of Polyfunctionalized Pyrroles <i>via</i> Green Chemical Methods

Abstract

Water was found to be an excellent solvent for the one‐pot synthesis of tetrasubstituted pyrrole derivatives under ultrasound involving the standard Knoevenagel condensation followed by the Michael type reaction. A new catalyst free system, excellent atom economy, ultrasound in water medium, short reaction times, good yields (88–93%), and ease of workup make this protocol more attractive and economically viable. The resulting substituted pyrroles are characterized by 1 H and 13 C NMR, elemental analysis, and mass spectral data.