Synthesis of substituted 4-hydroxyalkyl-quinoline derivatives by a three-component reaction using CuCl/AuCl as sequential catalysts

Abstract

A new method to construct 4-hydroxyalkyl-quinoline derivatives is described <italic>via</italic> Cu(<sc>i</sc>) and Au(<sc>i</sc>) sequential catalyzed cyclization of anilines with aldehyde derivatives and aliphatic alkynes, respectively.