Clinical and Histopathological Effects of Heart Failure Drug Therapy in Advanced Heart Failure Patients on Chronic Mechanical Circulatory Support

Abstract

Clinical and histopathological evidence showed that adjuvant HF drug therapy was associated with additional favourable effects on the structure and function of the unloaded myocardium that extended beyond the beneficial effects attributed to LVAD-induced unloading alone. Adjuvant HF drug therapy did not influence the incidence of major post-LVAD adverse events during the follow-up period.