A facile method for urinary phenylalanine measurement on paper-based lab-on-chip for PKU therapy monitoring

Concepts

EngineeringBioengineeringPharmacologyBiosensorsMolecular DiagnosticsTherapeutic Drug MonitoringBiopotential MeasurementPoint-of-care BiosensingPoint-of-care Diagnostic DevicesLab-on-a-chipLab-on-a-chip DevicesLab-on-a-chip PlatformsMeasurementPaper-based Analytical DevicesPaper-based BiosensorsPaper-based SensorsUrine Biomarkers

Abstract

A miniaturized paper-based lab-on-chip (LoC) was developed for the facile measurement of urinary Phe (phenylalanine) level on PKU (Phenylketonuria) treated patient. This system permits the monitoring of Phe in a dynamic range concentration of 20-3000 μM.

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