Bacteriocin-like inhibitory activities of seven <i>Lactobacillus delbrueckii</i> subsp. <i>bulgaricus</i> strains against antibiotic susceptible and resistant <i>Helicobacter pylori</i> strains

Abstract

In this study, anti-Helicobacter pylori activity of seven Lactobacillus delbrueckii subsp. bulgaricus (GLB) strains was evaluated by four cell-free supernatant (CFS) types. The GLB strains produced heat-stable bacteriocin-like inhibitory substances (BLISs) with a strong anti-H. pylori activity and some neutralized, catalase- and heat-treated CFSs inhibited >83% of the test strains. Bacteriocin-like inhibitory substance production of GLB strains can render them valuable probiotics in the control of H. pylori infection.