Concepedia

Publication | Closed Access

Reduced Serotonin Transporter Levels and Inflammation in the Midbrain Raphe of 12 Month Old APP<sub>swe</sub>/PSEN<sub>1dE9</sub> Mice

DOI

13

Citations

0

References

2018

Year

Athanasios Metaxas, Ramanan Vaitheeswaran, Katrine Tækker Jensen, Camilla Thygesen, Sultan Darvesh, Bente Finsen
Current Alzheimer Research

Abstract

There was no amyloid accumulation and tau-associated pathology in the midbrain raphe of 12 month old APPswe/PS1dE9 mice. However, there was a local neuroinflammatory response with loss of serotonergic markers, which may partially account for some of the behavioral symptoms of AD.