The <scp>HMGB</scp> 1 is increased in <scp>CSF</scp> of patients with an Anti‐ <scp>NMDAR</scp> encephalitis

Abstract

Our results showed significant increases in CSF HMGB1, IL-6, and IL-17A (P < .05) in anti-NMDAR encephalitis patients. But between 3 months' mRS scores in anti-NMDAR encephalitis patients and CSF data, there was no correlation. Our study suggests that HMGB1 CSF levels are increased in patients with anti-NMDAR encephalitis and reflect the underlying neuroinflammatory process.