Fresh Frozen Plasma (FFP)

Abstract

Fresh frozen plasma is indicated for the deficiency of coagulation factors with abnormal coagulation tests in the presence of active bleeding. FFP is also indicated for a planned surgery or invasive procedure in the presence of abnormal coagulation tests, for the reversal of warfarin in the presence of active bleeding or planned procedure when vitamin K is inadequate to reverse the warfarin effect, thrombotic thrombocytopenic purpura, and congenital or acquired factor deficiency with no alternative therapy. Other more specific recommendations for FFP based on systematic review include trauma patients requiring massive transfusion and warfarin-related intracranial hemorrhage.