Multimodal Bioactivation of Hydrophilic Electrospun Nanofibers Enables Simultaneous Tuning of Cell Adhesivity and Immunomodulatory Effects

Abstract

Abstract Biomaterials research usually focuses on functional and structural mimicry of the extracellular matrix or tissue hierarchy and morphology. Most recently, material‐induced modulatory effects on the immune system to arouse a healing response is another upcoming strategy. Approaches, however, that integrate both aspects to induce healing and facilitate specific cell adhesion are so far little explored. This study exploits manifold but chemical crosslinker free functionalization of hydrophilic and nonadhesive electrospun fiber surfaces with peptides for controlled cell adhesion, and with neutra­lizing antibodies targeting the master cytokine tumor necrosis factor (TNF) to dampen proinflammatory reactions by the fiber adherent cells. It is demonstrated that cell attachment and immunomodulatory properties of a textile can be tailored at the same time to generate meshes that combine immunosuppressive activity with specific cell adhesion properties.