Pathologic Stimulus Determines Lineage Commitment of Cardiac C-kit⁺Cells

Abstract

These results demonstrate that different pathological stimuli induce different cell fates of c-kit⁺ cells in vivo. Although the overall rate of cardiomyocyte formation from c-kit⁺ cells is still below clinically relevant levels, we show that p53 is central to the ability of c-kit⁺ cells to adopt cardiomyocyte fates, which could lead to the development of strategies to preferentially generate cardiomyocytes from c-kit⁺ cells.