Comparative Study of Molecularly Imprinted Polymer and Magnetic Molecular Imprinted Nanoparticles as Recognition Sites for the Potentiometric Determination of Gemifloxacin Mesylate

Abstract

Two nanoparticles based potentiometric sensors were fabricated for the selective determination of gemifloxacin mesylate. The first sensor was based on the formation of molecularly imprinted polymer nanoparticles using methacrylic acid as a functional monomer, trimethylolpropane trimethacrylate as a crosslinker and azobisisobutyronitrile as the initiator. The second sensor was based on the use of Fe 3 O 4 magnetic nanoparticles as core shells for the molecularly imprinted polymer. The developed sensors showed high selectivity, stability and sensitivity with wide concentration ranges of 1×10 -3 - 1×10 -8 mol L -1 and 1×10 -3 - 1×10 -10 mol L -1 for sensors 1 and 2, respectively. They were efficiently applied for the determination of gemifloxacin mesylate in bulk, pharmaceutical tablets and spiked human plasma.