Emergence of Various NDM-Type-Metallo-β-Lactamase-Producing Escherichia coli Clinical Isolates in Nepal

Abstract

Of 250 clinical isolates of <i>Escherichia coli</i> obtained in Nepal, 38 were carbapenem resistant, with MICs of imipenem or meropenem of ≥4 μg/ml. All 38 isolates harbored the following <i>bla</i>_NDMs: <i>bla</i>_NDM-1, <i>bla</i>_NDM-3, <i>bla</i>_NDM-4, <i>bla</i>_NDM-5, <i>bla</i>_NDM-7, <i>bla</i>_NDM-12, and <i>bla</i>_NDM-13 Most of these isolates also harbored the 16S rRNA methylase gene(s) <i>armA</i>, <i>rmtB</i>, and/or <i>rmtC</i>.