Maternal Multivitamin Intake, Plasma Folate and Vitamin B₁₂Levels and Autism Spectrum Disorder Risk in Offspring

Abstract

There was a 'U shaped' relationship between maternal multivitamin supplementation frequency and ASD risk. Extremely high maternal plasma folate and B₁₂ levels at birth were associated with ASD risk. This hypothesis-generating study does not question the importance of consuming adequate folic acid and vitamin B₁₂ during pregnancy; rather, raises new questions about the impact of extremely elevated levels of plasma folate and B₁₂ exposure in-utero on early brain development.