Systemic inflammation mediates the detrimental effects of obesity on asthma control - Concepedia

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Systemic inflammation mediates the detrimental effects of obesity on asthma control

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2017

Year

Xin Zhang, Jing Zheng, Li Zhang, Ying Liu, Gai Ping Chen, Hong Ping Zhang, Lei Wang, De Ying Kang, Lisa G. Wood, Gang Wang

Allergy and Asthma Proceedings

Abstract

Our mediation analysis confirmed that systemic inflammation biomarkers, such as leptin, CCL17, IL-4, and IL-13, mediated the effects of obesity on asthma control. This warrants prospective exploration in this distinct asthma phenotype in the future.