Anatomy, Skin (Integument)

Abstract

The skin is the largest and primary protective organ in the body, covering its entire external surface and serving as a first-order physical barrier against the environment. Its functions include temperature regulation and protection against ultraviolet (UV) light, trauma, protection from pathogens, microorganisms, and toxins. The skin also plays a role in immunologic surveillance, sensory perception, control of insensible fluid loss, and homeostasis in general. The skin is also highly adaptive with different thicknesses and specialized functions in different body sites. This article will discuss the anatomy of the skin, including its structure, function, embryology, blood, lymphatic, and nerve supply, surgical, and clinical significance.