Influence of atrial contraction dynamics on cardiac function

Abstract

In recent years, there has been a move from monoventricular or biventricular models of the heart, to more complex models that incorporate the electromechanical function in all 4 chambers. However, the biophysical foundation is still underdeveloped, with most work in atrial cellular models having focused on electrophysiological properties. Here, we present a biophysical model of human atrial contraction at body temperature and use it to study the effects of atrial contraction on whole organ function and a study of the effects of remodelling due to atrial fibrillation on atrial and ventricular function.