Science Signaling · 2017 · 107 citations · 41 references
Life SciencesCell BiologyImmunologyImmunoregulationInnate ImmunityReproductive ImmunologyImmune Cell SignalingNatural Killer Cell BiologyNatural Killer Cell FunctionNatural Killer Cell RegulationPregnancy ImmunologyRegulatory T CellsC-jun N-terminal Kinase SignalingImmunosuppressive FunctionJun N-terminal Kinase SignalingMaternal-fetal ImmunologyMaternal-fetal ToleranceT Cell Immunoglobulin And Mucin-domain Containing-3 RegulationT-cell Immunoglobulin Domain-containing Protein 3T-cell Mucin Domain-containing Protein 3
pNK cells, reduced fetal loss in abortion-prone and NK cell-deficient mice. Together, our findings reveal a critical role for Tim-3-Gal-9 signaling-mediated immunoregulation by pNK cells in maternal-fetal immune tolerance and suggest that Tim-3 abundance on pNK cells is a potential biomarker for RM diagnosis.
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Selective inhibition of BET bromodomains
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The accessible chromatin landscape of the human genome
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The Tim-3 ligand galectin-9 negatively regulates T helper type 1 immunity
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