Nanoscale Research Letters · 2017 · 113 citations · 30 references
Natural SciencesBioengineeringMaterials ScienceNanobiotechnologyNanomaterialsPolymer ChemistryMagnetic NanomaterialsNanoparticle CharacterizationNanoparticle StabilityOptical BiosensingPolymeric NanomaterialsProtein AdsorptionMagnetic NanoparticlesNanoparticle Surface CoatingNanoparticle Surface FunctionalizationNanoparticle Surface PropertiesNanoparticlesOptical PropertiesPoint-of-care Optical SensingSurface Optical Properties
and Au nanoparticles. Coating GoldMag with polymers not only increases the stability of the composite particles suspended in buffer but also plays a key role for establishing point-of-care optical tests for clinically relevant biomolecules. In the present paper, poly(4-styrenesulfonic acid-co-maleic acid) (PSS-MA), a negatively charged polyelectrolyte with both sulfonate and carboxylate anionic groups, was used to coat the positively charged GoldMag (30 nm) surface. The PSS-MA-coated GoldMag complex has a stable plasmon resonance adsorption peak at 544 nm. A pair of anti-D-dimer antibodies has been coupled on this GoldMag composite nanoparticle surface, and a target protein, D-dimer was detected, in the range of 0.3-6 μg/mL. The shift of the characteristic peak, caused by the assembly of GoldMag due to the formation of D-dimer-antibody sandwich bridges, allowed the detection.
30
Xiong Liu, Qiu Dai, Lauren A. Austin et al. · Journal of the American Chemical Society · 2008 · 671 citations · Full text
Fan Xia, Xiaolei Zuo, Renqiang Yang et al. · Proceedings of the National Academy of Sciences · 2010 · 536 citations · Full text