Concepedia

Visible-light promoted γ-cyanoalkyl radical generation: three-component cyanopropylation/etherification of unactivated alkenes

Linyong Li, Haoguo Chen, Mingjing Mei, Lei Zhou

Chemical Communications · 2017 · 169 citations · 38 references

DOI

Concepts

Abstract

A photoredox approach to generate distal cyano-substituted alkyl radicals through C-C bond cleavage of cyclobutanone oximes was developed. The radicals produced by this method were applied to three-component cyanopropylation/etherification of unactivated alkenes. Their reactions with diverse radical acceptors were also demonstrated.

References

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