Impact of Atherosclerosis‐ and Diabetes‐Related Dicarbonyls on Vascular Endothelial Permeability: A Comparative Assessment

Abstract

Our comparative study demonstrates that MDA is more damaging to the endothelial barrier than GO or MGO. Considering that MDA endogenous levels exceed those of GO or MGO and tend to increase further during lipoperoxidation, it appears important to reduce oxidative stress and, in particular, MDA levels in order to prevent sustained vascular hyperpermeability in atherosclerosis and diabetes patients.