Novel Mutation of <i>LRP6</i> Identified in Chinese Han Population Links Canonical WNT Signaling to Neural Tube Defects

Abstract

Our results suggested that over-active canonical WNT signaling induced by gain-of-function mutation in LRP6 could also contribute to human NTDs, and a balanced WNT/β-catenin and PCP signaling is probably required for proper neural tube development. Birth Defects Research 110:63-71, 2018. © 2017 Wiley Periodicals, Inc.