[Retracted] Enantioselective Rh- or Ir-catalyzed Directed C(sp³)–H Borylation with Phosphoramidite Chiral Ligands

Abstract

Enantioselective heteroatom-directed C(sp3)–H borylation reactions of 2-aminopyridines and 2-alkylpyridines with Rh- and Ir catalytic systems using commercially available chiral monophosphine ligands, respectively, were developed. This methodology provides an innovative example of a homogeneous catalytic system for C(sp3)–H borylation, and allows the direct synthesis of optically active alkylboronates with a moderate level of enantioselectivity. Enantioselective heteroatom-directed C(sp3)–H borylation reactions of 2-aminopyridines and 2-alkylpyridines with Rh- and Ir catalytic systems using commercially available chiral monophosphine ligands, respectively, were developed. This methodology provides an innovative example of a homogeneous catalytic system for C(sp3)–H borylation, and allows the direct synthesis of optically active alkylboronates with moderate enantioselectivity.