Hydroethanolic extract of <i>Carthamus tinctorius</i> induces antidepressant-like effects: modulation by dopaminergic and serotonergic systems in tail suspension test in mice.

Abstract

Our findings firstly showed that components (especially N-Hexadecanoic acid) of CT extract induce antidepressant-like effects by interaction with dopaminergic (D1 and D2) and serotonergic (5HT1A, 5-HT2A receptors) systems. These findings validate the folk use of CT extract for the management of depression.