Frontotemporal Dementia Caused by the P301L Mutation in<b> </b>the<b><i> MAPT</i></b> Gene: Clinicopathological Features of 13 Cases from the Same Geographical Origin in Barcelona, Spain

Abstract

These findings suggest a relative homogeneous clinicopathological phenotype in P301L MAPT mutation carriers in our series. This phenotype might help in the differential diagnosis from other tauopathies and be a morphological hint for genetic testing. The haplotype analysis results suggest a founder effect of the P301L mutation in this area.