Biomechanical and Hemodynamic Measures of Right Ventricular Diastolic Function: Translating Tissue Biomechanics to Clinical Relevance

Abstract

RV pressure overload in PAB rats resulted in an increase in diastolic myocardial stiffness reflected both hemodynamically, by an increase in E_ed, and biomechanically, by an increase in longitudinal E₁. Modest increases in tissue biomechanical stiffness are associated with large increases in E_ed. Hemodynamic measurements of RV diastolic function can be used to predict biomechanical changes in the myocardium.