Asymmetric Synthesis of Spirooxindole δ‐Lactones with Vicinal Tertiary and Quaternary Stereocenters via Regio‐, Diastereo‐, and Enantioselective Organocatalytic Vinylogous Aldol‐cyclization Cascade Reaction

Abstract

Abstract A highly region‐, diastereo‐, and enantioselective organocatalytic vinylogous aldol‐cyclization cascade reaction of prochiral 3‐akylidene oxindoles to isatins has been achieved by using bifuctional organocatalysts. A variety of enantioenriched spirooxindole δ‐lactones with vicinal tertiary and quaternary stereocenters were generated in good to excellent yields with good to high diastereoselectivities and enantioselectivities. magnified image