<i>Curcumin longa</i> extract-loaded nanoemulsion improves the survival of endotoxemic mice by inhibiting nitric oxide-dependent HMGB1 release

Abstract

The present study shows for the first time the mechanism by which <i>C. longa</i> ameliorates sepsis, namely, by suppressing NO signaling and thereby inhibiting the release of the proinflammatory cytokine HMGB1. These observations suggest that identification of agents, including those in the herb <i>C. longa</i>, that can inhibit HMGB1 production and/or activity may aid the treatment of endotoxemia.