Effect of TALEN-mediated IL-6 knockout on cell proliferation, apoptosis, invasion and anti-cancer therapy in hepatocellular carcinoma (HCC-LM3) cells

Abstract

IL-6 has no direct effect on cell proliferation and invasion but promotes tumor cell apoptosis <i>in vitro</i> study. Sorafenib and combination therapies are suitable for HCC cells with low or no IL-6 expression confirmed <i>in vivo</i> study.