Alcohol Reduces Arterial Remodeling by Inhibiting Sonic Hedgehog‐Stimulated Stem Cell Antigen‐1 Positive Progenitor Stem Cell Expansion

Abstract

EtOH reduces SHh-responsive Sca1⁺ progenitor cell myogenic differentiation/expansion in vitro and during arterial remodeling in response to ligation injury in vivo. Regulation of vascular Sca1⁺ progenitor cells in this way may be an important novel mechanism contributing to alcohol's cardiovascular protective effects.