Fe ₃ O ₄ @SiO ₂ @propyl‐ANDSA: A new catalyst for the synthesis of tetrazoloquinazolines

Abstract

In this paper, a mild and green protocol has been developed for the synthesis of quinazoline derivatives. The catalytic activity of 7‐aminonaphthalene‐1,3‐disulfonic acid‐functionalized magnetic Fe 3 O 4 nanoparticles (Fe 3 O 4 @SiO 2 @Propyl–ANDSA) was investigated in the one‐pot synthesis of new derivatives of tetrahydrotetrazolo[1,5‐a]quinazolines and tetrahydrobenzo[h]tetrazolo[5,1‐b]quinazolines from the reaction of aldehydes, 5‐aminotetrazole, and dimedone or 6‐methoxy‐3,4‐dihyronaphtalen‐1(2H)‐one at 100 °C in H 2 O/EtOH as the solvent. The catalyst was characterized before and after the organic reaction. Fe 3 O 4 @SiO 2 @Propyl–ANDSA showed remarkable advantages in comparison with previous methods. Advantages of the method presented here include easy purification, reusability of the catalyst, green and mild procedure, and synthesis of new derivatives in high yields within short reaction time.