Lupus‐Associated Functional Polymorphism in <i>PNP</i> Causes Cell Cycle Abnormalities and Interferon Pathway Activation in Human Immune Cells

Abstract

The PNP rs1049564 T allele is a loss-of-function variant that induces S-phase block and IFN pathway activation in lymphocytes. The S-phase block could be rescued in our in vitro experiments, suggesting the potential for personalized treatment.