Publication | Closed Access
Facile oxidative cyclization to access C2-quaternary 2-hydroxy-indolin-3-ones: synthetic studies towards matemone
13
Citations
39
References
2017
Year
Materials ScienceBioorganic ChemistryEngineeringBiochemistryOxidative CyclizationSynthetic StudiesQuaternary CentreNatural SciencesSustainable SynthesisOrganic ChemistryCatalysisSynergistic OxidationChemistrySynthesis MethodNatural Product SynthesisSynthetic ChemistryFacile Oxidative CyclizationAccess C2-quaternary 2-Hydroxy-indolin-3-ones
Synergistic oxidation can do it! The precursor for matemone can be facilely prepared in 21% overall yield in 8 steps. The key step is the oxidative cyclization by utilizing CAN and TEMPO to install the quaternary centre.
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