Hydroxycarbamide in children with sickle cell anaemia after first‐dose <i>vs</i>. chronic therapy: pharmacokinetics and predictive models for drug exposure

Abstract

Children naïve to hydroxycarbamide exhibit a different PK profile compared to children receiving chronic therapy. Accuracy of population-based dosing is sufficient to target AUCs in individual patients. Further clearance/bioavailability studies are needed to address the factors responsible for variability in the disposition of hydroxycarbamide.