′′One‐Pot′′ Selective Synthesis of 3,4‐Disubstituted Pyrroles and Benzo[f]indole‐4,9‐diones from 1,3‐Indanedione, Aromatic Aldehydes and TosMIC

Abstract

Abstract A variety of 3,4‐disubstituted pyrroles and benzo[f]indole‐4,9‐diones have been selectively synthesized from readily available aromatic aldehydes, 1,3‐Indanedione and tosylmethyl isocyanide (TosMIC) by a one‐pot procedure in high yields. This methodology features operationally simple, practical with broad substrate scope and usage of easy to handle reagents. The one‐pot sequential reactions proposed to proceeds through a tandem in situ generated chalcones and [3+2]‐cycloaddition/ring cleavage or expansion process.