MiR‐21‐Mediated Suppression of Smad7 Induces <scp>TGF</scp>β1 and Can Be Inhibited by Activation of Nrf2 in Alcohol‐Treated Lung Fibroblasts

Abstract

Alcohol treatment increases TGFβ1 in fibroblasts, at least in part, through augmentation of miR-21, which then inhibits Smad7 expression. These effects can be attenuated by activation of Nrf2 with SFP.