Biocompatible Nickel-Prussian Blue@Silver Nanocomposites Show Potent Antibacterial Activities

Abstract

Herein, we report a simple and cost-effective method for the synthesis of nickel-prussian blue@silver nanocomposites. The nanocomposite is highly stable and shows biocompatibility observed by <i>in vitro</i> assay and by <i>ex vivo</i> chicken embryonic angiogenesis assay. The nanocomposite exhibits profound antibacterial activity toward Gram-negative (<i>Escherichia coli</i>) and Gram-positive (<i>Bacillus subtillus</i>) bacteria. The results altogether suggest the future potential applications of nickel-prussian blue@silver nanocomposite as an antibacterial agent.