A protective role of <scp>IRF</scp>3 and <scp>IRF</scp>7 signalling downstream <scp>TLR</scp>s in the development of vein graft disease via type I interferons - Concepedia

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A protective role of <scp>IRF</scp>3 and <scp>IRF</scp>7 signalling downstream <scp>TLR</scp>s in the development of vein graft disease via type I interferons

DOI Full Paper Access

14

Citations

33

References

2017

Year

Karin H. Simons, Hendrika A. B. Peters, J. Wouter Jukema, Margreet R. de Vries, Paul H.A. Quax

Journal of Internal Medicine

Abstract

The present study is the first to describe a protective role of both IRF3 and IRF7 in VGD. IRFs regulate VGD downstream TLRs since Irf3<sup>-/-</sup> and Irf7<sup>-/-</sup> vein grafts show increased vessel wall thickening after respectively 14 and 28 days after surgery.

References

	Year	Citations

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