Intracellular Oxidation-Reduction Studies

Abstract

ABSTRACT A New approach to the problems of cellular metabolism was opened by J. and D. Needham (8) who used the micro-injection of reversible indicators to determine the oxidation-reduction intensity of living protoplasm. Prerequisites for this work were the elaboration of a series, as yet incomplete, of such indicators, and the electrometric standardisation of the position of each dye on the scale of reduction (or oxidation) electrode potential by Clark, Cohen and their co-workers (1, 4, 5, 7). Discussions of the various theoretical phases of oxidation-reduction and their possible applications to the study of life processes are found in the papers of Clark and Cohen (5).