HLA polymorphisms and risk of red blood cell alloimmunisation in polytransfused patients with sickle cell anaemia

Abstract

This study suggests that polytransfused patients with SCA possessing the HLA-DQB1*03 and HLA-C*06 allele variants are more susceptible to alloimmunisation. In addition, HLA-DRB1*04 and HLA-DRB1*11 alleles were seen to be associated with the production of anti-Fy^a and anti-K antibodies, respectively.