Autoimmune Epilepsy and/or Limbic Encephalitis Can Lead to Changes in Sleep Spindles

Abstract

The sleep abnormalities in LE can result from the disruption of thalamo-limbic circuits, and lead to changes in spindle wave activity. Although density of spindles decreased with acute lesions in thalamo-limbic circuits, the relations with structural lesions or chronicity of disease are not clear. That may be related to functional disruption of neural circuitry.