Cognition and gray and white matter characteristics of presymptomatic <i>C9orf72</i> repeat expansion

Abstract

This study demonstrates that a decline in cognitive functioning, white matter integrity, and gray matter volumes are present in presymptomatic <i>C9orf72RE</i> carriers. These findings suggest that neuropsychological assessment, T1-weighted MRI, and diffusion tensor imaging might be useful to identify early biomarkers in the presymptomatic stage of FTD or amyotrophic lateral sclerosis.