Direct means of obtaining CAVI₀—a corrected cardio-ankle vascular stiffness index (CAVI)—from conventional CAVI measurements or their underlying variables

Abstract

Our results permit straightforward calculation of [Formula: see text] during a study, as well as retrospective estimation of [Formula: see text] from CAVI_VS in already published studies or where the original transit time values are not available, paving the way for thorough comparison of CAVI₀ to CAVI_VS in clinical and research settings. Novelty and significance Cardio-ankle vascular index (CAVI) as measured using the VaSera device (CAVI_VS, Fukuda Denshi), has been proposed as a blood pressure-independent arterial stiffness index. We have recently shown theoretically that CAVI_VS still exhibits pressure dependence, and proposed a corrected index, CAVI₀. In the present study, we derived equations to directly obtain CAVI₀ using data from the VaSera device. Our results permit straightforward calculation of [Formula: see text] during a study, as well as retrospective estimation of [Formula: see text] from CAVI_VS in already published studies, paving the way for thorough comparison of CAVI₀ to CAVI_VS in clinical and research settings.