α₁‐Adrenergic Receptors Function Within Hetero‐Oligomeric Complexes With Atypical Chemokine Receptor 3 and Chemokine (C‐X‐C motif) Receptor 4 in Vascular Smooth Muscle Cells

Abstract

α₁-ARs form hetero-oligomeric complexes with the ACKR3:CXCR4 heteromer, which is required for α_1B/D-AR function, and activation of ACKR3 negatively regulates α₁-ARs. G protein-coupled receptor hetero-oligomerization is a dynamic process, which depends on the relative abundance of available receptor partners. Endogenous α₁-ARs function within a network of hetero-oligomeric receptor complexes.