Role of IQGAP3 in metastasis and epithelial–mesenchymal transition in human hepatocellular carcinoma

Abstract

IQGAP3 functions as an important regulator of metastasis and EMT by constitutively activating the TGF-β signaling pathway in HCC. Our findings present new evidence of the role of IQGAP3 in EMT and metastasis, indicating its potential as a prognostic biomarker candidate and a therapeutic target against HCC.